Brain Connectivity Patterns in Chronic Temporomandibular Joint Disorders

Completed

Conditions studied: Chronic Pain, Temporomandibular Joint Disorders, Temporomandibular Joint Pain

In brief

This study addresses the timely problem of painful temporomandibular disorders (TMD), the most common cause of orofacial pain second only to tooth pain. Findings from previous studies suggest that dysregulation of connectivity within specific brain circuits is part of chronic pain pathophysiology. This study will identify connectivity patterns within those brain circuits as potential signatures for pain- related disability in chronic TMD pain participants. New knowledge regarding these brain connectivity patterns is expected to be significant because it will support improved phenotyping of this heterogeneous participant population. It is also expected that this finding can potentially be extrapolated to other chronic pain conditions, such as back pain, migraine headache, and fibromyalgia that are frequently comorbid conditions in chronic TMD participants.

Key facts

Study ID
NCT05068908
Run by
University of Minnesota
People needed
75
Starts
2022-03-02
Expected to finish
2026-06-24
Last updated by the study team
2026-07-10

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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