Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease

Recruiting now · Not applicable

Conditions studied: Dupuytren's Disease

In brief

Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand. It develops a progressive contractile fibrosis which cuts the hypodermic fatty tissue, adheres to the skin and the phalanges, gradually bending the affected rays, resulting in significant functional impotence. Various medical and surgical treatments are available.

Key facts

Study ID

NCT05067764

Run by

Elsan

People needed

172

Starts

2022-09-29

Expected to finish

2030-03-29

Last updated by the study team

2026-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Carrier of Tubiana stage II-IV Dupuytren's disease on at least one or more rays, not previously operated
• Indication of a surgery by aponeurectomy
• Skin pinch of the posterior aspect of the arm of more than 1cm
• Affiliation to a social security system
• Patient informed of the study and having given informed consent

You may not qualify if…

• Previous surgery of any kind for Dupuytren's disease
• Involvement on the thumb only
• Need for a total skin graft or a pedicle flap on all the rays to be treated
• Active autoimmune disease
• Previous treatment with collagenase
• Pregnant and breastfeeding women
• Patient under legal protection
• Contraindications to MRI (criteria applicable only for patients from the coordinating center, not applicable for other centers)

Where it is running

• Institut Aquitain de la Main — Pessac, France (enrolling)
• Santé Atlantique ELSAN — Saint-Herblain, France (enrolling)

Full record on ClinicalTrials.gov

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