Amygdala Memory Enhancement

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury, Cognitive Impairment, Post Traumatic Stress Disorder

In brief

The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

Key facts

Study ID

NCT05065450

Run by

Washington University School of Medicine

People needed

90

Starts

2021-11-01

Expected to finish

2027-11-01

Last updated by the study team

2025-07-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be able to understand and speak English.
• Able to provide informed consent.
• Diagnosed with epilepsy.
• Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization.
• Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices.

You may not qualify if…

• Unable to understand and speak English.
• Unable to provide informed consent.
• Not diagnosed with epilepsy.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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