Multiple-Ascending Dose in Japanese Patients Bridging Study

Completed · Phase 1 · Has a placebo group

Conditions studied: Healthy

In brief

This study is a randomized, placebo-controlled, multiple-ascending dose study in healthy Japanese and Caucasian subjects.

Key facts

Study ID

NCT05065359

Run by

Altavant Sciences GmbH

People needed

47

Starts

2021-10-01

Expected to finish

2022-03-30

Last updated by the study team

2022-07-13

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy males or females aged 18 to 55 years, inclusive
• A male subject is eligible to participate if he does not have a female partner who is pregnant or who intends to become pregnant during the study. Male subjects must agree to use contraception starting at Screening, during the treatment period, and for at least 100 days after the last dose of Investigational Product (IP), and refrain from donating sperm during this period.
• Female subjects of childbearing potential must agree to use contraception starting at Screening, during the treatment period, and for at least 30 days after the last dose of IP.
• Body mass index (BMI) ≥ 18 kg/m2 and ≤ 32 kg/m2 at Screening
• Japanese subjects must have been born in Japan and not have lived outside of Japan > 10 years at the time of Screening, have both parents and grandparents of ethnic Japanese origin, and have not significantly modified their diets since leaving Japan.
• Caucasian subjects must be of European or Latin American descent (i.e., White).
• Capable of giving signed informed consent, able to understand and comply with protocol requirements, instructions, and protocol related restrictions, and likely to complete the study as planned.

You may not qualify if…

• Any known pre-existing medical or psychiatric condition that could interfere with the subject's ability to provide informed consent or participate in study conduct, or that may confound study findings including, but not limited to a history of clinically significant gastrointestinal, hematologic, renal, hepatic, bronchopulmonary, neurological, psychiatric, or cardiovascular disease
• a. History of Gilbert's Syndrome
• b. History of depression
• c. History of any allergy that, in the opinion of the Investigator, contraindicates participation in the trial
• Any positive finding on the Columbia-Suicide Severity Rating Scale (C-SSRS).
• Donation of plasma within 7 days prior to dosing. Donation or loss of blood (excluding volume drawn at Screening) of 50 mL to 499 mL of blood within 30 days or more than 499 mL within 56 days prior to Day 1
• Participation in an investigational drug, vaccine, or device study within 30 days before IP administration or 90 days for a biologic study
• Evidence of previous myocardial infarction
• a. Any conduction abnormality (including but not specific to atrioventricular block [2nd degree or higher], Wolff Parkinson White syndrome [unless curative ablation treatment]).
• b. Sinus pauses > 3 seconds.
• c. Any significant arrhythmia which, in the opinion of the Investigator and Medical Monitor, will interfere with the safety for the individual subject.
• d. Non-sustained or sustained ventricular tachycardia (≥ 3 consecutive ventricular ectopic beats).
• Abnormal blood pressure, either low (defined as < 90 mmHg systolic and/or < 50 mmHg diastolic) or high (defined as > 140 mmHg systolic and/or > 90 mmHg diastolic)
• Clinically significant abnormalities in laboratory test results (including hepatic and renal panels, complete blood count, coagulation, chemistry panel, and urinalysis)
• a. Positive serology for hepatitis B, hepatitis C virus, or human immunodeficiency virus
• b. Estimated glomerular filtration rate < 80 mL/min/1.73 m2
• c. Aspartate aminotransferase, alanine aminotransferase values greater than 1.5 x upper limit of normal.
• d. Positive urine test for drugs of abuse
• e. Positive alcohol test (breath, saliva, or urine)
• Use of prescription or nonprescription drugs including high dose vitamins, dietary supplements (including St. John's Wort) within 7 days or 5 half-lives of the prescription or nonprescription drug (whichever was longer) prior to the first dose of IP product, unless in the opinion of the Investigator and Sponsor, the medication would not interfere with the study outcomes or compromise subject safety.
• Subject unable to abstain from consumption of tryptophan-rich foods 48 hours prior to admission to the clinic through the Follow-up visit
• Consumption of grapefruit or Seville oranges or their juices within the 7 days prior to dosing until collection of the final PK sample.
• Use of medications associated with QT prolongation within 30 days prior to dosing and during the study. A list of prohibited medications is provided in an appendix to the protocol.
• Subjects unable to abstain from alcohol for 72 hours prior to the start of dosing through collection of their final PK sample
• Subjects with a clinical history of or current alcohol abuse defined as an average weekly intake of more than 21 units for males or 15 units for females (1 unit = 340 mL beer, 115 mL wine, or 43 mL spirits).

Where it is running

• California Clinical Trials Medical Group (CCTMG) — Glendale, California, United States

Full record on ClinicalTrials.gov

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