A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Alzheimer Disease

In brief

The purpose of this study is to assess the safety, tolerability and effect of study drug LY3372689 in participants with early symptomatic Alzheimer's Disease

Key facts

Study ID

NCT05063539

Run by

Eli Lilly and Company

People needed

327

Starts

2021-09-16

Expected to finish

2025-05-22

Last updated by the study team

2026-06-12

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Gradual and progressive change in memory function reported by participants or informants for ≥ 6 months
• MMSE score of 22 to 30 (inclusive) at screening
• CDR global score of 0.5 to 1.0 (inclusive), with a memory box score ≥0.5.
• Meet 18F flortaucipir positron emission tomography (PET) scan (central analysis) criteria
• Have a study partner who will provide written informed consent to participate

You may not qualify if…

• Contraindication to MRI or PET scans
• Have known allergies to LY3372689, related compounds, or any components of the formulations

Where it is running

• Hope Clinical Research, Inc. — Canoga Park, California, United States
• Neuro-Pain Medical Center — Fresno, California, United States
• Irvine Clinical Research — Irvine, California, United States
• Sharp Mesa Vista Hospital — San Diego, California, United States
• Institute for Neurodegenerative Disorders — New Haven, Connecticut, United States
• JEM Research Institute — Atlantis, Florida, United States
• VIN-Julie Schwartzbard — Aventura, Florida, United States
• Neurology Offices of South Florida — Boca Raton, Florida, United States
• Brain Matters Research — Delray Beach, Florida, United States
• Neuropsychiatric Research Center of Southwest Florida — Fort Myers, Florida, United States
• K2 Medical Research — Maitland, Florida, United States
• ClinCloud - Viera — Melbourne, Florida, United States
• Merritt Island Medical Research, LLC — Merritt Island, Florida, United States
• VIN-Andrew Lerman — Miami, Florida, United States
• IMIC, Inc. — Miami, Florida, United States
• VIN-Victor Faradji — Miami, Florida, United States
• Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• VIN- Margarita Almeida El-Ramey — Pembroke Pines, Florida, United States
• Brain Matters Research — Stuart, Florida, United States
• Charter Research - Lady Lake — The Villages, Florida, United States
• Josephson Wallack Munshower Neurology, PC — Indianapolis, Indiana, United States
• Boston Center for Memory — Newton, Massachusetts, United States
• Donald S. Marks M.D., P.C. — Plymouth, Massachusetts, United States
• HammondCare Greenwich Hospital — Sydney, New South Wales, Australia

Full record on ClinicalTrials.gov

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