Brain Tumor Intraoperative Ultrasound Database

Completed

Conditions studied: Brain Tumor, Brain Neoplasms, Brain Cancer, Glioma, Glioblastoma

In brief

Predicting the survival of patients diagnosed with glioblastoma (GBM) is essential to guide surgical strategy and subsequent adjuvant therapies. Intraoperative ultrasound (ioUS) is a low-cost, versatile technique available in most neurosurgical departments. The images from ioUS contain biological information possibly correlated to the tumor's behavior, aggressiveness, and oncological outcomes. Today's advanced image processing techniques require a large amount of data. Therefore, the investigators propose creating an international database aimed to share intraoperative ultrasound images of brain tumors. The acquired data must be processed to extract radiomic or texture characteristics from ioUS images. The rationale is that ultrasound images contain much more information than the human eye can process. Our main objective is to find a relationship between these imaging characteristics and overall survival (OS) in GBM. The predictive models elaborated from this imaging technique will complement those already based on other sources such as magnetic resonance imaging (MRI), genetic and molecular analysis, etc. Predicting survival using an intraoperative imaging technique affordable for most hospitals would greatly benefit the patients' management.

Key facts

Study ID

NCT05062772

Run by

Hospital del Rio Hortega

People needed

150

Starts

2022-05-25

Expected to finish

2024-11-14

Last updated by the study team

2024-11-15

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients operated between January 2018 and January 2020 with a pathological diagnosis of WHO grade IV astrocytoma (Glioblastoma).
• Intraoperative ultrasound study that includes B-mode images

You may not qualify if…

• Other histopathological diagnoses. Even though the international database will be established in such a way that other tumor types can be included prospectively.
• Artifacts in ultrasound images that make their analysis impossible
• Stereotactic biopsies.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Hôpital Bretonneau, CHRU de Tours — Tours, France
• Tata Memorial Centre — Mumbai, Parel, India
• Fondazione Irccs Istituto Neurologico "Carlo Besta" — Milan, Italy
• Unit of Neurosurgery, Department of Biomedicine Neurosciences and Advanced Diagnsotics, University of Palermo — Palermo, Italy
• University Hospital Rio Hortega — Valladolid, Spain

Full record on ClinicalTrials.gov

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