A Trial of LY3056480 in Patients With SNLH
Withdrawn before enrolling · Phase 2 · Has a placebo group
Conditions studied: Sensorineural Hearing Loss
In brief
A phase 2 trial with LY3056480 in patients with stable SNHL
Key facts
- Study ID
- NCT05061758
- Run by
- Audion Therapeutics BV
- People needed
- 0
- Starts
- 2022-09-01
- Expected to finish
- 2025-03-01
- Last updated by the study team
- 2022-08-25
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female between 18 - 65 years of age;
- Minimum of six months of documented stable hearing loss (+/- 5dB);
- A documented stable word recognition test (stable for \~ 6 months +/- 6%/3 words)
You may not qualify if…
- Presenting with a primary complaint of tinnitus
- Any conductive hearing loss of greater than 15 dB at a single frequency or greater than 10 dB at two or more contiguous octave frequencies in the study ear
- History of suspected or diagnosed genetic cause of hearing loss;
- Partial deafness as defined as hearing loss in any frequency (up to 8 kHz) greater than 80dB
- Suspected or known diagnosis of the following inner ear pathology, congenital hearing loss, fluctuating hearing loss, Ménière's disease, or secondary endolymphatic hydrops, perilymph fistula, cochlear barotrauma, autoimmune hearing loss, radiation-induced hearing loss, retro-cochlear lesion, ototoxicity
- Evidence of acute or chronic otitis media or otitis externa on examination; or a history of middle ear pathology and/or surgery (except for ear tubes as a child)
- Any therapy known as ototoxic
- Participant in a previous trial of LY3056480
Where it is running
- Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States
- New York Eye and Ear Infirmary ICAHN school of Medicine Mount Sinai — New York, New York, United States
- Eastern Virginia Medical School — Norfolk, Virginia, United States
Full record on ClinicalTrials.gov
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