Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics

Recruiting now

Conditions studied: Breast Carcinoma

In brief

This study compares synthetic mammography to full-field digital mammography in image interpretation and performance metrics. Digital breast tomosynthesis (DBT) has previously been found to be superior in performance to standard digital mammography in both screening and diagnostic settings for the early detection and improved diagnosis of breast cancers. DBT in combination with full-field digital mammography (FFDM) reduces recall rates and increases cancer detection rates relative to FFDM alone. Synthetic mammography is a 2-dimensional reconstructed image, using the dataset derived from the DBT acquisition, without requiring additional radiation dose. Collecting information from patients' medical records may help doctors analyze the characteristics, utility, and impact of synthetic mammography to compared to FFDM.

Key facts

Study ID

NCT05056818

Run by

M.D. Anderson Cancer Center

People needed

750

Starts

2020-12-15

Expected to finish

2026-10-31

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female
• Age 18 or older
• Consecutive cases in breast imaging center

You may not qualify if…

• Cases demonstrate administrative or technical errors (e.g. missing views, labeling inconsistent with report, etc.)

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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