Penn SICCA Follow-up Study

Starting soon

Conditions studied: Dry Eye, Sjogren's Syndrome

In brief

This study will involve the collection of follow-up data for patients who previously participated in the Sjogren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Clinical data and specimens will be collected from subjects with objective evidence of dry eye who were or were not diagnosed with Sjogren's syndrome at the time of their initial participation in the SICCA study. Specimens will be collected from participants which will include tears, saliva, whole blood, serum, DNA and possible labial minor salivary gland biopsies when indicated. All individuals will participate in a standard evaluation protocol including an oral, ocular and physical examination, objective tests for dry eyes and dry mouth and, whenever necessary, a labial minor salivary gland biopsy. The biopsy requirement is waived for those who have already had positive lip biopsies in the past.

Key facts

Study ID

NCT05056012

Run by

University of Pennsylvania

People needed

220

Starts

2027-01-01

Expected to finish

2029-01-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previously participated in the SICCA study at Penn
• Be 18 years or older
• Have signed an IRB consent form agreeing to the terms of the study

You may not qualify if…

• Did not previously participate in SICCA study at Penn
• Under the age of 18 years

Where it is running

• Scheie Eye Institute — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.