Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
Recruiting now
Conditions studied: Endometrial Cancer, Cervical Cancer, Atypical Endometrial Hyperplasia, Cervical Dysplasia, Adnexal Mass, Ovarian Cancer
In brief
The overarching objective of this project is to develop a pan-gynecologic cancer detection test using gynecologic (unique endometrial, cervical, and ovarian cancer) cancer-specific methylated DNA markers and high-risk human papilloma virus (HR-HPV) detected in vaginal fluid and/or plasma. This proposal defines Phase II MDM-based cancer detection studies in endometrial cancer (EC) and endometrial hyperplasia with atypia (AEH) in vaginal fluid and 2) ovarian cancer (OC) in plasma and vaginal fluid. Additionally, it defines necessary Phase I MDM-based cancer detection and exploratory aims to test novel cervical cancer (CC) MDMs and test the specificity of cancer-specific MDMs among various common benign gynecologic pathologies.er detection and exploratory aims to test novel cervical cancer MDMs and test the specificity of cancer-specific MDMs among various common benign gynecologic pathologies.
Key facts
- Study ID
- NCT05051722
- Run by
- Mayo Clinic
- People needed
- 3110
- Starts
- 2021-08-03
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-04-17
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic — Phoenix, Arizona, United States (enrolling)
- Mayo Clinic — Jacksonville, Florida, United States (enrolling)
- Medical Colleagues of Texas, LLP — Katy, Texas, United States (enrolling)
- Virginia Commonwealth University/ Massey Cancer Center — Richmond, Virginia, United States (enrolling)
- Mayo Clinic Health System - Northwest Wisconsin — Eau Claire, Wisconsin, United States (enrolling)
- Mayo Clinic Health System - Southwest Wisconsin — La Crosse, Wisconsin, United States (enrolling)
- Genoma Research, Inc. — Miami, Florida, United States (enrolling)
- Orlando Health — Orlando, Florida, United States (enrolling)
- Sarasota Memorial Health Care System — Sarasota, Florida, United States (enrolling)
- Piedmont Healthcare — Atlanta, Georgia, United States (enrolling)
- University of Chicago — Chicago, Illinois, United States (enrolling)
- Ochsner Clinic Foundation — New Orleans, Louisiana, United States (enrolling)
- Valley OB-GYN Clinic — Saginaw, Michigan, United States (enrolling)
- Mayo Clinic — Rochester, Minnesota, United States (enrolling)
- University of Mississippi Medical Center — Jackson, Mississippi, United States (enrolling)
- The Woman's Health Pavilion — Howard Beach, New York, United States (enrolling)
- The Woman's Health Pavilion — Westbury, New York, United States (enrolling)
- Altru Health System — Grand Forks, North Dakota, United States (enrolling)
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
- Total Women's Care of the Heights — Houston, Texas, United States (enrolling)
- My GYN Care — Miami, Florida, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Providea Health Partners, LLC — Evergreen Park, Illinois, United States
- Signature Women's Healthcare, LLC — Pembroke Pines, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.