A Study of LY3502970 in Participants With Obesity or Overweight With Weight-related Comorbidities

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Overweight and Obesity

In brief

The main purpose of the study was to assess the effect of LY3502970 in participants who have obesity or are overweight.

Key facts

Study ID

NCT05051579

Run by

Eli Lilly and Company

People needed

272

Starts

2021-09-29

Expected to finish

2022-11-22

Last updated by the study team

2023-09-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) of ≥30-kilogram square meter (kg/m²)
• Have a BMI ≥27 kg/m² and <30 kg/m² with at least 1 of the following weight-related comorbidities eg; [Have hypertension, or dyslipidemia, cardiovascular disease]
• Have had a stable body weight for the 3 months prior to randomization (not more than 5% body weight gain and/or loss)

You may not qualify if…

• Have any prior diagnosis of diabetes
• Have a prior or planned surgical treatment for obesity
• Have obesity induced by other endocrinological disorders or diagnosed monogenetic or syndromic forms of obesity
• Have renal impairment measured as estimated glomerular filtration rate (eGFR) <30 milliliter (mL)/minute (min)/1.73 m²
• Have a history of acute chronic pancreatitis
• Have a history of significant active or unstable Major Depressive Disorder (MDD) or other severe psychiatric disorder (for example, schizophrenia, bipolar disorder, or other serious mood or anxiety disorder) within the last 2 years Note: Participants with MDD or generalized anxiety disorder whose disease state is considered stable for the past 2 years and expected to remain stable throughout the course of the study, may be considered for inclusion if they are not on excluded medications.
• Within 3 months prior to screening:
• Have poorly controlled hypertension
• Have history of acute myocardial infarction
• Have history of cerebrovascular accident (stroke)
• Had hospitalization due to congestive heart failure (CHF)
• Have cancer
• Have human immunodeficiency virus (HIV) and/or positive HIV antibodies historically or at screening
• Have hepatitis B and/or positive hepatitis B surface antigen

Where it is running

• Anaheim Clinical Trials, LLC — Anaheim, California, United States
• John Muir Physician Network Research Center — Concord, California, United States
• NorCal Medical Research, Inc — Greenbrae, California, United States
• Valley Clinical Trials, Inc. — Northridge, California, United States
• Norcal Endocrinology & Internal Medicine — San Ramon, California, United States
• Elite Clinical Trials — Blackfoot, Idaho, United States
• Rocky Mountain Clinical Research — Idaho Falls, Idaho, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Premier Research — Trenton, New Jersey, United States
• Lillestol Research — Fargo, North Dakota, United States
• Intend Research, LLC — Norman, Oklahoma, United States
• Capital Area Research, LLC — Camp Hill, Pennsylvania, United States
• Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair — Pittsburgh, Pennsylvania, United States
• Dallas Diabetes Research Center — Dallas, Texas, United States
• Diabetes and Thyroid Center of Fort Worth — Fort Worth, Texas, United States
• Texas Diabetes & Endocrinology, P.A. — Round Rock, Texas, United States
• National Clinical Research, Inc — Richmond, Virginia, United States
• St. Vincent Hospital d/b/a Prevea Health — Green Bay, Wisconsin, United States
• C-health Research — Calgary, Alberta, Canada
• Wharton Medical Clinic — Hamilton, Ontario, Canada
• Bluewater Clinical Research Group Inc. — Sarnia, Ontario, Canada
• Centre Médical et Professionnel de l'Ouest de Portneuf — Saint-Marc-des-Carrieres, Quebec, Canada
• Alpha Recherche Clinique — Québec, Canada
• ALPHA Recherche Clinique — Québec, Canada
• Studium Egeszseghaz Kft — Kalocsa, Bács-Kiskun county, Hungary

Full record on ClinicalTrials.gov

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