AlloSure Lung Assessment and Metagenomics Outcomes Study

Running, not enrolling

Conditions studied: Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection

In brief

ALAMO is a prospective, multi-center, perspective, registry of patients receiving LungCare™ (AlloSure®-Lung, AlloMap Lung, and HistoMap) for surveillance post-transplant. This study aims to evaluate the diagnostic performance characteristics of AlloSure Lung (dd-cfDNA) to detect a spectrum of rejection (ACR, AMR) and allograft infection (Bacterial, Viral, Fungal, Mycobacterial, Parasitic).

Key facts

Study ID

NCT05050955

Run by

CareDx

People needed

550

Starts

2021-10-29

Expected to finish

2028-12-31

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Unilateral or Bilateral, deceased-donor, initial or re-transplant
• ≤ 90 days post-transplant
• Ability to understand and provide informed consent and adhere to laboratory surveillance schedule
• Patients who have LungCare initiated within 30 days of signing the informed consent form

You may not qualify if…

• Multi-organ transplants
• Pregnancy
• Active malignancy

Where it is running

• University of Alabama (UAB) — Birmingham, Alabama, United States
• St. Joseph's Hospital & Medical Center — Phoenix, Arizona, United States
• Cedars Sinai Medical Center — Los Angeles, California, United States
• University of California (UCSF) School of Medicine — San Francisco, California, United States
• University of CO Anschutz Medical Campus — Aurora, Colorado, United States
• AdventHealth Orlando — Orlando, Florida, United States
• Loyola University Medical School — Maywood, Illinois, United States
• University of Louisville Health — Louisville, Kentucky, United States
• University of Mayland — Baltimore, Maryland, United States
• Brigham and Womens Hospital — Boston, Massachusetts, United States
• Washington University-Barnes Jewish Hospital — St Louis, Missouri, United States
• NYU Langone Health — New York, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Ohio State University — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Temple University — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• UT Health/ Memorial Hermann Hospital — Houston, Texas, United States
• Inova — Falls Church, Virginia, United States
• University of Wisconsin Madison — Madison, Wisconsin, United States
• Toronto General Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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