Screening for Individual Susceptibility Factors to Immersion Pulmonary Edema

Recruiting now · Not applicable

Conditions studied: Pulmonary Edema

In brief

Immersion Pulmonary Edema (IPE) is a relatively new form of hemodynamic pulmonary edema. The number of cases has been increasing over the last ten years and it has become the second most common cause of hospitalization for military divers, after decompression sickness. The pathophysiological mechanisms of IPE are not completely known. Its occurrence is linked to a combination of factors related to the environmental constraints of diving, as well as to the diver's equipment. The main external factors are increased hydrostatic pressure, cold, intense effort and emotional stress. The impact of internal factors is not known. At this time, no severe forms of IPE have been identified in the military. However, it is important to identify this pathology at an early stage, even if the signs appear minor, because the continuation of underwater activity can significantly worsen the clinical picture. The risk of recurrence (greater than 15%) could result in a severe or even lethal accident.

Key facts

Study ID

NCT05049889

Run by

Direction Centrale du Service de Santé des Armées

People needed

63

Starts

2022-08-17

Expected to finish

2026-08-01

Last updated by the study team

2022-09-14

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Military or civilian diver with at least 100 dives
• Between the ages of 18 and 60
• Good physical condition (able to run/swim for 30 minutes at a constant pace).

You may not qualify if…

• Divers with a current temporary medical incapacity to dive
• Persons with contraindications to physical exercise and/or scuba diving
• Pregnant or breastfeeding women

Where it is running

• Equipe Résidente de Recherche Subaquatique Opérationnelle — Toulon, France (enrolling)
• Hôpital d'Instruction des Armées Sainte-Anne — Toulon, France (enrolling)

Full record on ClinicalTrials.gov

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