A Study of LY3502970 in Participants With Type 2 Diabetes Mellitus
Completed · Phase 2 · Has a placebo group
Conditions studied: Type 2 Diabetes
In brief
The main purpose of this study is to evaluate the efficacy and safety of LY3502970 in participants with type 2 diabetes (T2D) who failed to achieve adequate glycemic control on diet and exercise alone or on a stable dose of metformin. This study will last about 30 weeks.
Key facts
- Study ID
- NCT05048719
- Run by
- Eli Lilly and Company
- People needed
- 383
- Starts
- 2021-09-15
- Expected to finish
- 2022-09-30
- Last updated by the study team
- 2023-10-17
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have been diagnosed with Type 2 Diabetes on diet and exercise and/or a stable dose of metformin
- Have a stable body weight for the 3 months prior to randomization
- Have a body mass index (BMI) ≥23 kilogram/square meter (kg/m²)
- Males must agree to use highly effective methods of contraception
- Women not of childbearing potential (WNOCBP) may participate in this trial
- Note: Hormone replacement therapy in post-menopausal women is allowed but women must be on stable therapy for 3 months prior to day 1.
You may not qualify if…
- Have Type 1 diabetes mellitus (T1DM) or history of ketoacidosis or hyperosmolar coma
- Have a history of diabetic retinopathy, diabetic maculopathy, or severe non-proliferative diabetic retinopathy that requires immediate treatment intervention
- Have had more than 1 episode of severe hypoglycemia and aware of hypoglycemic symptoms
- Have acute or chronic pancreatitis
- Have obesity induced other endocrine disorders (Cushing's syndrome or Prader - Willi syndrome)
- Have gastric emptying abnormality or chronically take medications impacting GI motility
- Have poorly controlled hypertension
- Have the following heart conditions within the last 6 months: myocardial infarction (MI), unstable angina, coronary artery bypass graft, percutaneous coronary intervention (diagnostic angiograms are permitted), transient ischemic attack (TIA), cerebrovascular accident (stroke)or decompensated congestive heart failure, or IV heart failure
- Have any symptoms of other liver diseases besides nonalcoholic fatty liver disease (NAFLD)
- Have HIV, or Hepatitis B or Hepatitis C
Where it is running
- Anaheim Clinical Trials, LLC — Anaheim, California, United States
- Velocity Clinical Research, Huntington Park — Huntington Park, California, United States
- Velocity Clinical Research, Westlake — Los Angeles, California, United States
- Rancho Cucamonga Clinical Research — Rancho Cucamonga, California, United States
- Touro University California — Vallejo, California, United States
- New West Physicians Clinical Research — Golden, Colorado, United States
- Optumcare Colorado Springs - Monument — Monument, Colorado, United States
- Cotton O'Neil Clinical Research Center — Topeka, Kansas, United States
- Clinvest Research LLC — Springfield, Missouri, United States
- Premier Research — Trenton, New Jersey, United States
- Intend Research, LLC — Norman, Oklahoma, United States
- Capital Area Research, LLC — Camp Hill, Pennsylvania, United States
- Family Medical Associates — Levittown, Pennsylvania, United States
- Tristar Clinical Investigations — Philadelphia, Pennsylvania, United States
- Dallas Diabetes Research Center — Dallas, Texas, United States
- Biopharma Informatic, LLC — Houston, Texas, United States
- Bandera Family Health Care — San Antonio, Texas, United States
- Consano Clinical Research, LLC — Shavano Park, Texas, United States
- Capital Clinical Research Center — Olympia, Washington, United States
- Eastside Research Associates — Redmond, Washington, United States
- Bugát Pál Kórház — Gyöngyös, Heves County, Hungary
- Kanizsai Dorottya Korhaz — Nagykanizsa, Zala County, Hungary
- Zala Megyei Szent Rafael Kórház — Zalaegerszeg, Zala County, Hungary
- Szent Margit Rendelőintézet Nonprofit Kft — Budapest, Hungary
- Clinexpert Kft. — Budapest, Hungary
Full record on ClinicalTrials.gov
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