Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation
Completed · Not applicable
Conditions studied: End Stage Liver DIsease, Liver Failure
In brief
This is a prospective, multi-center, controlled, randomized, pivotal study to evaluate the safety and effectiveness of the VitaSmart™ Liver Machine Perfusion System by comparing clinical outcomes in patients undergoing liver transplantation with ex-vivo liver preservation using static cold storage (SCS) followed by hypothermic oxygenated machine perfusion (HOPE) versus SCS only.
Key facts
- Study ID
- NCT05045794
- Run by
- Bridge to Life Ltd.
- People needed
- 228
- Starts
- 2021-12-16
- Expected to finish
- 2024-05-31
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Loma Linda University Medical Center — San Bernadino, California, United States
- University of California San Francisco — San Francisco, California, United States
- Stanford University Medical Center — Stanford, California, United States
- Mayo Clinic — Jacksonville, Florida, United States
- Cleveland Clinic — Weston, Florida, United States
- Indiana University — Indianapolis, Indiana, United States
- Ochsner Clinic Foundation — New Orleans, Louisiana, United States
- Lahey Hospital and Medical Center — Burlington, Massachusetts, United States
- Henry Ford Hospital — Detroit, Michigan, United States
- Washington University St. Louis — St Louis, Missouri, United States
- Nebraska Medical Center — Omaha, Nebraska, United States
- Mount Sinai Hospital — New York, New York, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- Houston Methodist Hospital — Houston, Texas, United States
- University of Wisconsin Madison — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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