Improving Age-Related Cognitive Decline With Exercise in Hypertensive Older Adults

Completed · Not applicable

Conditions studied: Hypertension

In brief

The investigator aims to assess the extent to which a brief exercise intervention improves systemic growth factor concentrations, reverses loss of systemic vascular networks and hypertension, and by extension, improves neurocognition. To test the investigator's hypothesis that increased cardiovascular fitness will correlate with improved vascular density, the investigator proposes the innovative use of retinal density scans.

Key facts

Study ID

NCT05043454

Run by

University of Alabama at Birmingham

People needed

11

Starts

2021-10-01

Expected to finish

2025-07-09

Last updated by the study team

2026-02-27

Who can join

Age: 55 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adults between 55-75 years of age
• essential hypertension (as determined by referring physicians)
• engages in less than 150 minutes of moderate intensity exercise/week (as determined by CHAMPS Questionnaire)
• physically able to exercise
• access to an upright cycle ergometer at home or via gym access
• access to smart device (iOS or Android phone or tablet with ability to install and use Polar Beat and Polar FlowTM applications).

You may not qualify if…

• diagnosis of dementia
• resting systolic blood pressure <120, or >180 mm Hg
• disease or condition that would preclude exercise
• untreated depression or anxiety disorders
• severe respiratory disease
• disease of the eye
• refractive error > 6 diopters or +6 diopters (as assessed by 1st retinal scan).

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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