Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation

Completed

Conditions studied: Extracorporeal Membrane Oxygenation, Children, Neurologic Injury

In brief

The BEAM study is a multicenter, prospective, observational study in children supported on extracorporeal membrane oxygenation (ECMO). The primary goals of this study are to develop and refine a brain injury multimarker panel for accurate neurologic monitoring at the bedside and early classification of mortality and disability outcomes of critically ill children supported on ECMO.

Key facts

Study ID

NCT05041712

Run by

Johns Hopkins University

People needed

455

Starts

2019-12-06

Expected to finish

2025-05-05

Last updated by the study team

2025-06-04

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children (2 days to <18 years) cannulated onto ECMO and admitted to a pediatric or cardiac Intensive Care Unit at participating institutions.

You may not qualify if…

• ECMO cannulation at an outside institution with transport to a study site >24 hours after ECMO initiation
• Limitation of care (e.g., family planning to withdraw support)
• Brain death evaluation within 24 hours of ECMO cannulation
• Inability to speak or understand English or Spanish
• Pregnancy.

Where it is running

• Children's Hospital Los Angeles — Los Angeles, California, United States
• University of California Los Angeles — Los Angeles, California, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Riley Hospital for Children — Indianapolis, Indiana, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• St. Louis Children's Hospital — St Louis, Missouri, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• University of Tennessee Health Science Center — Memphis, Tennessee, United States
• Texas Children's Hospital — Houston, Texas, United States
• Seattle Children's Hospital — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.