Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients

Recruiting now · Not applicable

Conditions studied: Neuroendocrine Tumor of Pancreas, Multiple Endocrine Neoplasia Type 1

In brief

Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET). The management of small (pNET) in both MEN1 and sporadic cases, pose a major clinical challenge. At present, pancreatic surgery is the only curative treatment but it is associated with high morbidity. To reduce the morbidity ascosiated with surgery and thereby potentially improve quality of life for MEN1 patients introduction of less invasive techniques for treatment of pNET is important. High-dose-high precision MR-guided radiotherapy (MRgRT) holds promise as a new less invasive treatment option for pNET. The aim of this study is to assess efficiacy and safety of MRgRT for treatment of pNET in MEN1 patients.

Key facts

Study ID: NCT05037461
Run by: J.M. de Laat
People needed: 20
Starts: 2022-05-01
Expected to finish: 2026-12-01
Last updated by the study team: 2024-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

Suspected malignant pNET as per the tumour board assessment, including the criteria:
pNET lesions of more than 3 cm in size
rapid growth of pNET lesions with more than 4mm per year
Symptomatic pNET because of hormone production, with the exception of gastrinomas which are located in the submucosa of the duodenum
concurrent treatment with a somatostatin analog
concurrent treatment with chemotherapy
peptide receptor radionuclide therapy in the past 12 months
history of radiotherapy in the upper abdominal region
MRI contraindications as per usual clinical care, such as claustrophobia and metal or electronic implants not compatible with MRI.
Pregnancy
(Other) metastatic disease
WHO performance score 3-4

Where it is running

UMC Utrecht — Utrecht, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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