Anti-Leukemia Immune Responses After Irradiation of Extramedullary Tumors

Running, not enrolling · Early Phase 1

Conditions studied: Acute Myeloid Leukemia, Myeloid Leukemia, Recurrent Acute Myeloid Leukemia

In brief

This clinical trial assesses how the immune system responds to leukemia tumors after low dose radiation delivered as part of standard of care. The information learned in this study may help them know if adding immunotherapy (a type of treatment that uses the immune system to fight cancer) can be helpful in future leukemia patients receiving radiation.

Key facts

Study ID

NCT05035706

Run by

M.D. Anderson Cancer Center

People needed

10

Starts

2021-06-30

Expected to finish

2026-04-30

Last updated by the study team

2026-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients diagnosed with new or recurrent myeloid leukemia
• Aged >= 18 years old
• Eastern Cooperative Oncology Group (ECOG) performance status < 4
• Patient have measurable and amenable to biopsy under local anesthesia without the need for imaging directed procedure
• Ability to understand and provide signed informed consent
• Females must be surgically or biologically sterile or postmenopausal (amenorrhoeic for at least 12 months) or if of childbearing potential, must have a negative serum or urine pregnancy test within 72 hours before the start of the treatment. Women of childbearing potential must agree to use an adequate method of contraception during the study and until the last radiation treatment. Males must be surgically or biologically sterile or agree to use an adequate method of contraception during the study and until the last radiation treatment

You may not qualify if…

• Patients who are unwilling to participate
• Patients unwilling to undergo the biopsy before or after radiotherapy

Where it is running

• M D Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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