Measurement of Brain Perfusion by a MR Perfusion Imaging Called eASL in Children's Cerebral Arteriopathies.
Recruiting now
Conditions studied: Cerebral Arteriopathy
In brief
The MR sequence called MR-ASL is used to measure cerebral perfusion in children. This ASL sequence is used with a unique post-labeling delay (PLD) due to the technical impossibility of setting different post-labeling delays. The use of a single post-labeling, chosen by the pediatric radiology department of the Necker hospital, optimal in children without arteriopathy, may not be suitable for the lengthened arterial transit time of the spins marked in the pathological carotid network of a child with arterial disease. Recently, ASL sequences with multiple delays (multi-PLD, called eASL) have been developed to overcome this limitation in arterial disease. To date, their use in the pre- and post-treatment evaluation of a child with acute or chronic arterial disease has not been evaluated. The study hypothesis is that this eASL sequence is more efficient than single-delay ASL in measuring cerebral perfusion. The study will be performed in a population of children with acute or chronic arterial disease.
Key facts
- Study ID
- NCT05026060
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 50
- Starts
- 2022-05-02
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2025-09-15
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Minor patients aged 0 to 18 with acute or chronic arterial disease: diagnosis of Moya-moya, diagnosis of sickle cell disease, acute and chronic arterial infarction.
- Necessity of diagnostic MR with standard ASL sequences for the care.
- Holders of parental authority and patients informed and not opposed to their participation in the study.
You may not qualify if…
- Usual contraindications to MR.
- Movement during ASL / eASL sequences.
Where it is running
- Hôpital Necker-Enfants Malades — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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