Bioavailability of Berberine and Dihydroberberine and Their Impact on Glycemia

Completed · Not applicable · Has a placebo group

Conditions studied: Glycemia

In brief

The purpose of this study is to determine the bioavailability of berberine and dihydroberberine and their impact on changes in plasma concentrations of glucose and insulin.

Key facts

Study ID

NCT05021341

Run by

Lindenwood University

People needed

5

Starts

2020-06-22

Expected to finish

2020-11-04

Last updated by the study team

2021-08-25

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• All participants will be between the ages of 18-45 years.
• Participants will be healthy and free of disease as determined by evaluation of a medical history
• Body mass index (BMI) between 18.5 - 30 kg/m\^2

You may not qualify if…

• Those individuals less than 18 and greater than 45 years of age will be excluded.
• Participants younger than 18 are excluded due to necessity of parental consent.
• Participants greater than 45 years old lie outside of the target demographic for the current study.
• As indicated on a medical history form they complete, any individual who is currently being treated for or diagnosed with any cardiac, respiratory, endocrine, psychiatric, musculoskeletal, renal, hepatic, neuromuscular or metabolic disease or disorder.
• Additional exclusion criteria include: participants with a fasting capillary blood glucose level > 100 mg/dL.
• Current smokers (including vaping) or have quit within the past six months.
• Any over-the-counter or prescription drugs and/or dietary supplements that are known or are purported to impact glycemia and insulinemia.
• Currently or have been following with the past 30 days a ketogenic or very-low carbohydrate diet.
• Participants who are determined to not be weight stable defined as measured body mass deviating by 2% or more.

Where it is running

• Lindenwood University — Saint Charles, Missouri, United States

Full record on ClinicalTrials.gov

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