Trem-1 and Ultraviolet Radiation-induced Immune Suppression

Running, not enrolling · Early Phase 1

Conditions studied: Skin Diseases

In brief

The overall goal of this study is to determine novel mechanisms for ultraviolet light (UV)-induced suppression of the immune system in human subjects and to improve understanding of UV-induced skin carcinogenesis.

Key facts

Study ID

NCT05020496

Run by

University of Alabama at Birmingham

People needed

70

Starts

2022-03-21

Expected to finish

2027-10-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Patients Fitzpatrick IV-VI
• A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation
• Patients with eczema, psoriasis, and contact dermatitis
• A known history of photosensitivity disorders
• A known history of melanoma or non-melanoma skin cancers
• Those planning on going to the tanning parlors
• Using any of the photosensitizing medication
• A woman who is lactating, pregnant, or planning to become pregnant
• Patient planning on exposing the irradiated or control areas to the sun
• Patients with organ transplantation, an immunodeficiency disorder or the use of an immunosuppressive drug

Where it is running

• Whitaker Clinic — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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