A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Stopped early · Phase 2 · Has a placebo group
Conditions studied: Geographic Atrophy
In brief
This is a dose finding study designed to evaluate the efficacy, safety, and pharmacokinetics of danicopan in participants with GA secondary to AMD. The study consists of a Screening Period of up to 6 weeks, a 104-week masked Treatment Period, followed by a 30-day Follow-up after the last dose. This study will have 4 treatments arms: 100 milligrams (mg) twice daily (bid), 200 mg bid, 400 mg once daily (qd), and matching placebo.
Key facts
- Study ID
- NCT05019521
- Run by
- Alexion Pharmaceuticals, Inc.
- People needed
- 365
- Starts
- 2021-08-23
- Expected to finish
- 2025-01-21
- Last updated by the study team
- 2025-09-05
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Beverly Hills, California, United States
- Research Site — Encino, California, United States
- Research Site — Fresno, California, United States
- Research Site — Fullerton, California, United States
- Research Site — La Jolla, California, United States
- Research Site — Pasadena, California, United States
- Research Site — Sacramento, California, United States
- Research Site — San Mateo, California, United States
- Research Site — Walnut Creek, California, United States
- Research Site — Colorado Springs, Colorado, United States
- Research Site — Longmont, Colorado, United States
- Research Site — Waterford, Connecticut, United States
- Research Site — Clearwater, Florida, United States
- Research Site — Coral Springs, Florida, United States
- Research Site — Deerfield Beach, Florida, United States
- Research Site — Naples, Florida, United States
- Research Site — Palm Beach Gardens, Florida, United States
- Research Site — St. Petersburg, Florida, United States
- Research Site — Augusta, Georgia, United States
- Research Site — New Albany, Indiana, United States
- Research Site — West Des Moines, Iowa, United States
- Research Site — Hagerstown, Maryland, United States
- Research Site — Rosedale, Maryland, United States
- Research Site — Towson, Maryland, United States
- Research Site — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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