Olfactory Deficits in Neurologic Disease
Completed
Conditions studied: Alzheimer Disease, Traumatic Brain Injury, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Lewy Body Disease, Mild Cognitive Impairment
In brief
The goal of this study is to examine olfactory function in preclinical subjects or individuals with neurological diseases such as Probable Alzheimer's Disease (PRAD), Frontotemporal Dementias (FTD), Dementia with Lewy Bodies (DLB), Traumatic Brain Injury (TBI), and Amyotrophic Lateral Sclerosis (ALS).
Key facts
- Study ID
- NCT05019014
- Run by
- Massachusetts General Hospital
- People needed
- 201
- Starts
- 2011-08-10
- Expected to finish
- 2020-07-03
- Last updated by the study team
- 2021-08-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of Probable Alzheimer's Disease, prodromal Alzheimer's Disease, Frontotemporal Dementia, Mild Cognitive Impairment, or Dementia with Lewy Bodies or mild and moderate/severe TBI.
- Diagnosis of familial or sporadic ALS per El Escorial Criteria or individuals with known gene mutations associated with ALS (regardless of clinical phenotype).
- Age-matched controls
- Males and females with a minimum age of enrollment of 18 years. There is no maximum age of enrollment.
You may not qualify if…
- Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
- Current sinusitis or common cold or upper respiratory infection, nasal polyps, or sinusitis.
- Traumatic or congenital anosmia
- Current or recent (past 6 months) alcohol or substance dependence. A prior history of alcohol or substance abuse will not be grounds for exclusion.
- Pregnancy
- Severe cognitive dysfunction
- Pneumocephalus
- Basilar skull fracture
- Known CSF leak
- Facial fractures to include Lefort I, II or III
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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