Better Evidence and Translation for Calciphylaxis

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Calciphylaxis

In brief

This global platform study will evaluate multiple interventions, across several domains of therapeutic care, in adult patients with kidney failure and newly diagnosed calciphylaxis.

Key facts

Study ID

NCT05018221

Run by

University of Sydney

People needed

350

Starts

2021-08-26

Expected to finish

2029-12-01

Last updated by the study team

2025-08-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently receiving haemodialysis, or peritoneal dialysis that can be converted to haemodialysis, with planned ongoing haemodialysis a minimum of three times per week for at least the duration of the protocolised calciphylaxis treatments within this trial
• Have a new calciphylaxis ulcer present for less than 10 weeks
• Age ≥ 18 years
• Eligible for randomisation in at least one recruiting domain
• The participant and treating physician are willing and able to perform trial procedures

You may not qualify if…

• Nil

Where it is running

• Concord Repatriation General Hospital — Concord, New South Wales, Australia (enrolling)
• St George Hospital — Kogarah, New South Wales, Australia (enrolling)
• Liverpool Hospital — Liverpool, New South Wales, Australia (enrolling)
• John Hunter Hospital — New Lambton Heights, New South Wales, Australia (enrolling)
• Westmead Hospital — Westmead, New South Wales, Australia (enrolling)
• Sunshine Coast Hospital and Health Service — Birtinya, Queensland, Australia (enrolling)
• Princess Alexandra Hospital — Brisbane, Queensland, Australia (enrolling)
• Bundaberg Base Hospital — Bundaberg, Queensland, Australia (enrolling)
• Cairns Hospital — Cairns, Queensland, Australia (enrolling)
• Townsville Hospital — Douglas, Queensland, Australia (enrolling)
• Ipswich Hospital — Ipswich, Queensland, Australia (enrolling)
• Royal Melbourne Hospital — Melbourne, Victoria, Australia (enrolling)
• Sunshine Hospital (Western Health) — St Albans, Victoria, Australia (enrolling)
• Royal Perth Hospital — Perth, Western Australia, Australia (enrolling)
• Royal Adelaide Hospital — Adelaide, Australia (enrolling)
• Monash Medical Centre — Clayton, Australia (enrolling)
• Dunedin Hospital — Dunedin, New Zealand (enrolling)
• Auckland City Hospital (Auckland DHB) — Grafton, New Zealand (enrolling)
• North Shore Hospital (Waitemata DHB) — Takapuna, New Zealand (enrolling)
• Tauranga Hospital — Tauranga, New Zealand (enrolling)
• Whangarei Hospital — Whangarei, New Zealand (enrolling)

Full record on ClinicalTrials.gov

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