Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Aging

In brief

Nicotine enhances auditory-cognitive function because it mimics the brain's system for "paying attention" to important sounds amid distractions (for example, understanding speech in a noisy environment). In part, nicotine does this by activating inhibitory neurons in the auditory cortex. Since age-related hearing deficits result, in part, from the loss of inhibitory neurons in auditory cortex, this project will determine whether nicotine's effects can compensate for reduced inhibition in the aging auditory cortex and thereby restore auditory function. The investigators will use functional magnetic resonance imaging (fMRI) to measure the selectivity of responses in auditory cortex to tones of various frequencies. The investigators will measure the effects of nicotine (administered as chewing gum) and aging on these fMRI response properties. The investigators hypothesize that frequency selectivity will decrease with aging and increase following nicotine administration.

Key facts

Study ID

NCT05018117

Run by

University of California, Berkeley

People needed

44

Starts

2022-06-06

Expected to finish

2025-04-01

Last updated by the study team

2026-07-24

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency

You may not qualify if…

• deafness or excessive hearing loss
• smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
• history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
• regular use of prescription medications (excluding oral contraceptives)
• drug dependency

Where it is running

• University of California, Berkeley — Berkeley, California, United States

Full record on ClinicalTrials.gov

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