Dexamethasone in Total Knee Arthroplasty
Completed · Phase 4
Conditions studied: Total Knee Arthroplasty
In brief
The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
Key facts
- Study ID
- NCT05018091
- Run by
- Rush University Medical Center
- People needed
- 438
- Starts
- 2021-10-28
- Expected to finish
- 2025-05-30
- Last updated by the study team
- 2026-08-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age > 18 years
- Primary total knee arthroplasty
- Patients staying at least one night in the hospital after surgery
You may not qualify if…
- Same day discharge Age < 18 years Revision or partial total knee arthroplasty Corticosteroid use within 3 months prior to surgery Inflammatory arthritis Current systemic fungal infection Renal or liver failure Prior adverse reaction to corticosteroid Primary TKA requiring hardware removal
Where it is running
- Stanford University — Redwood City, California, United States
- University of California, San Francisco — San Francisco, California, United States
- Rush University medical Center — Chicago, Illinois, United States
- Mass General Brigham — Somerville, Massachusetts, United States
- Mayo Clinic Institutional Review — Rochester, Minnesota, United States
- Washington University — St Louis, Missouri, United States
- NYU Langone Health — New York, New York, United States
- Columbia University Irving Medical Center — New York, New York, United States
- University of Pennsylvania Perelman School of Medicine — Philadelphia, Pennsylvania, United States
- Jefferson Philadelphia University and Thomas Jefferson University — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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