NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
Recruiting now
Conditions studied: Antimicrobial Resistance (AMR)
In brief
This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel. It is to investigate antimicrobial resistance (AMR) including three clinical manifestations of infectious diseases: urinary tract infection, pneumonia and deep-seated infections. The focus is on four bacteria (E. coli, Klebsiella species, S. aureus, P. aeruginosa) that are part of the high priority list of World Health Organization (WHO). Residual patient samples are analysed for proteomic, metabolomic and transcriptomic analysis, immunocytochemical or fluorescence in-situ hybridisation (FISH) analysis, flow cytometry analysis (FACS) and immunophenotyping and exploration of bacterial properties.
Key facts
- Study ID
- NCT05017766
- Run by
- University Hospital, Basel, Switzerland
- People needed
- 8000
- Starts
- 2020-12-03
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2025-03-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients with confirmed (i) urinary tract infection, (ii) pneumonia (including patients after lung transplantation, cystic fibrosis) or (iii) deep-seated infection with focus pathogen:
- E. coli
- Klebsiella species
- S. aureus
- P. aeruginosa
- Controls: no detectable bacteria in routine microbiology lab and no other infection site at inclusion of the sample and follow up for 10 days, signed general consent
- Clinical controls without obtained samples, but with confirmed (i) urinary tract infection, (ii) pneumonia (including patients after lung transplantation, cystic fibrosis) or (iii) deep-seated infection with focus pathogen:
- E. coli
- Klebsiella species
- S. aureus
- P. aeruginosa
You may not qualify if…
- Patients who have refused research and reuse of their data/samples (e.g. general consent) or any other decline (e.g. Patientenverfügung).
- other than one of the focus bacteria in routine microbiology lab
- Age: <18 years
- Controls without signed general consent
Where it is running
- University Hospital Basel — Basel, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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