Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Recruiting now

Conditions studied: Atrial Fibrillation, Atrial Arrhythmia, Atrial Flutter, Atrial Tachycardia

In brief

The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize that patients with a higher baseline Utah fibrosis staging will experience a higher incidence of POAF. The study also aims to evaluate and compare the in-hospital mortality, length-of-stay (LOS), complication rates (strokes, pneumonia, respiratory failure etc.) of the different Utah fibrosis stage cohorts. Perform cost analysis and compare between patients with POAF and patients without POAF. The investigators hypothesize that patients experiencing POAF will have a higher mortality rate, longer LOS, greater complications, and therefore, additional hospital costs.

Key facts

Study ID: NCT05014802
Run by: Tulane University
People needed: 50
Starts: 2021-11-21
Expected to finish: 2026-12-01
Last updated by the study team: 2026-06-15

Who can join

Age: 40 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male or female patients age 40 years of age or older
Patients with no history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia) scheduled to undergo cardiac surgery (These surgeries include but are not limited to coronary artery bypass graft (CABG), valvular repair/reconstruction, aneurysm repair, and insertion of pacemaker).

You may not qualify if…

Patients with a history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia)
Patients with a history of cardiac or open chest surgery
Patients with a history of catheter ablation
Patients under the age of 40
Patients with left ventricular assist device (LVAD) or scheduled to have LVAD implanted
Patients who have previously undergone extracorporeal membrane oxygenation (ECMO)
Patients who have undergone or will undergo heart transplantation
Patients with any health related Late Gadolinium Enhancement (LGE)-MRI contraindications (including previous allergic reaction to gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
Acute or chronic severe renal disease with a low glomerular filtration rate (GFR), <30 mL per minute per 1.73 m2 will be excluded from the trial. (A creatinine measurement should be available within the last 6 months. If not, a creatinine blood test will be drawn to assess for renal function before the MRI acquisition).
Patients weighing > 300 lbs. (MRI image quality decreases due to increased body mass index)
Patients currently pregnant or breastfeeding, or plan to become pregnant during the study period
Patients with cognitive impairment preventing them from giving informed consent will be excluded from the study
Patients who cannot read, speak, and/or understand English

Where it is running

Lakeview Hospital — Covington, Louisiana, United States (enrolling)
East Jefferson General Hospital — New Orleans, Louisiana, United States (enrolling)
Washington University Barnes-Jewish Hospital — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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