Immunometabolic Mechanisms of Blood Flow Restriction (BFR) Training After Anterior Cruciate Ligament Reconstruction
Recruiting now · Not applicable
Conditions studied: Anterior Cruciate Ligament Reconstruction
In brief
This is a crossover phase 4 study to evaluate the impact of blood flow restriction on immunometabolism and gene expression in immune cells in individuals undergoing rehabilitation from anterior cruciate ligament reconstruction.
Key facts
- Study ID
- NCT05012982
- Run by
- Yale University
- People needed
- 20
- Starts
- 2023-02-16
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2025-12-03
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for two study visits at least 1 week apart
- All genders, between 18 and 60 years of age
- In good general health without any underlying medical conditions or prior injury that would place the subject at risk of further injury/illness by participating in the study
You may not qualify if…
- Serious medical conditions including cardiovascular, metabolic (diabetes), rheumatologic, pulmonary, or musculoskeletal.
- Multiple ligament ruptures or trauma
- Rheumatoid arthritis or other significant comorbidities
- Lower extremity vascular pathology, including history of deep vein thrombosis
- Those with a history of sickle cell trait or disease
- Use of anticoagulant medications
- Pregnancy
- Treatment with another investigational drug or other intervention within one month of Study Day 1
- Current smoker or tobacco use within 3 months of Study Day 1
- Febrile illness within 2 weeks of Study Day 1
Where it is running
- Yale New Haven Hospital — Milford, Connecticut, United States (enrolling)
- Gaylord Outpatient Physical Therapy North Haven Clinic — North Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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