Humidified Forest Oils for Immune System Recovery in Stage I-III Breast or Prostate Cancer

Completed · Not applicable

Conditions studied: Breast Carcinoma, Prostate Carcinoma

In brief

This clinical trial studies the feasibility of simulating forest therapy using humidified wood or fragrant oils, in improving immune cells, like natural killer cells, number and activity, and their downstream proteins, perforin and granulysin in patients with stage I-III breast or prostate cancer who completed chemo- and/or radiation therapy. The knowledge gained from this study may help cancer patients who have compromised immune systems and who also cannot participate in outdoor activities like exercise or forest walks.

Key facts

Study ID

NCT05012813

Run by

OHSU Knight Cancer Institute

People needed

28

Starts

2022-07-19

Expected to finish

2025-03-31

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 18 years. Both men and women and members of all races and ethnic groups will be included
• Participants must have histologically or cytologically confirmed breast cancer or prostate cancer (hormone therapy excepted) who are in stage I-V with or without evidence of metastasis using the Cancer Therapy Evaluation Program (CTEP) Simplified Disease Classification
• Participants must be within 12 months of their first diagnosis of breast or prostate cancer
• Criteria for solid tumors: Participants must have measurable disease, per doctor of medicine (MD) and data in medical record
• Participants must have no history of autoimmune disease
• Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

• If they have asthma. Rationale: forest oils may be a possible trigger for asthma
• If they have a known allergy to citrus peel or pine forests. Rationale: forest oils may cause contact dermatitis and coughing
• If they are unable to detect common odors from commercial fragrances. Rationale, forest oils are humidified as an aroma to be inhaled in the simulate the forest greenspace immersion (SFIT)
• First diagnosis of breast or prostate cancer is longer than 12 months ago. Rationale, NK cell number recovery may be complete by this time after first treatment
• Febrile illness/infection within previous two weeks. Rationale, immune biomarkers will reflect previous febrile illness
• Current tobacco or tobacco use within 1 hour of start of SFIT. Rationale: forest oils may cause contact dermatitis and coughing
• Prior autoimmune disease, are on immune-modulating therapies (endocrine therapy allowed). Rationale, because of their poor prognosis rather than being in early stages of cancer
• Had surgery or invasive procedure in the past two months. Rationale, because of their poor prognosis rather than being in early stages of cancer
• Inability to complete study requisites

Where it is running

• OHSU Knight Cancer Institute — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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