[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Recruiting now · Early Phase 1

Conditions studied: Cocaine Use Disorder

In brief

This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

Key facts

Study ID

NCT05011760

Run by

Rajesh Narendran

People needed

30

Starts

2021-01-31

Expected to finish

2028-09-01

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females between 18 and 55 years old
• Fulfil DSM-5 criteria for cocaine use disorder
• No other current DSM-5 psychiatric or addictive disorders (such as major depressive disorder, bipolar disorders, psychotic disorders, etc.,)
• No current abuse (six months) of opiates, sedative-hypnotics, amphetamines, and MDMA as well as moderate to severe alcohol or cannabis use (twice a week). Nicotine use will be quantified and controlled between groups using the Fagerstrom Test for Nicotine Dependence (Heatherton et al., 1991);
• Not currently on prescription medical or psychotropic medications
• No current or past severe medical, endocrine or neurological illnesses including glaucoma, seizure disorders, hypertension, hypercholesterolemia as assessed by a complete medical history and physical
• Not currently pregnant or breastfeeding
• No history of significant radioactivity exposure in past year from another research study or occupation that exceeds RDRC guidelines
• No metallic objects in the body that are contraindicated for MRI
• No baseline BP ≥ 140/90 and/or HR ≥ 100.
• No first-degree relative with an MI or stroke prior to middle age
• No first-degree relative with psychosis or mania.
• Completed a baseline [11C]NOP-1A PET scan in Aim 1 (Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)

Where it is running

• University of PIttsburgh — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.