Late Onset Alzheimer's Disease

Recruiting now

Conditions studied: Alzheimer Disease

In brief

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Key facts

Study ID

NCT05010603

Run by

Columbia University

People needed

10000

Starts

2016-11-15

Expected to finish

2027-04-30

Last updated by the study team

2026-05-18

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
• a living sibling with probable or possible AD;
• a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
• participants in the proband's generation with an identified companion serving as an informant;
• participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.

You may not qualify if…

• failure to identify an appropriate informant;
• uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
• discovery of additional diagnosis that could account for the clinical manifestations;
• unwillingness to participate;
• failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
• participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.

Where it is running

• University of Washington — Washington D.C., District of Columbia, United States (enrolling)
• University of Miami — Miami, Florida, United States (enrolling)
• Rush University — Aurora, Illinois, United States (enrolling)
• Indiana University — Bloomington, Indiana, United States (enrolling)
• NCRAD at Indiana University — Indianapolis, Indiana, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Joanne Norton — St Louis, Missouri, United States (enrolling)
• Columbia University Irving Medical Center — New York, New York, United States (enrolling)
• North Carolina State University — Raleigh, North Carolina, United States (enrolling)
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
• University of Texas Southwestern — Dallas, Texas, United States (enrolling)
• University of Washington — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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