Cortical Contributions to Frequency Following Responses and Modulation
Completed · Not applicable
Conditions studied: Language
In brief
The frequency-following response (FFR), a scalp-recorded neurophonic potential, is a widely used metric of speech encoding integrity in healthy and clinical human populations. The translational potential of the FFR as a biomarker is constrained by poor understanding of its neural generators and influencing factors. This study leverages a cross-species and cross-level approach to provide mechanistic insight into the properties of the cortical source of the FFR, and elucidate the role of cortical feedback via cortico-collicular projections on modulation of the FFR as a function of stimulus context, arousal state, and category relevance. This clinical trial will focus on the influences of category relevance, predictability, and participant arousal state on the FFRs in neurotypical human participants.
Key facts
- Study ID
- NCT05010473
- Run by
- Northwestern University
- People needed
- 73
- Starts
- 2022-01-20
- Expected to finish
- 2026-03-04
- Last updated by the study team
- 2026-04-24
Who can join
Age: 13 and older, up to 25. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 13 years up to 25 years
- Healthy volunteers
- Native English speaking individuals with no exposure or experience to tonal languages
- Native Mandarin speakers
- Hearing sensitivity within normal limits (Puretone hearing thresholds < 25dB from 250
- Hz to 8000 Hz)
- Less than six years of formal music training or experience
You may not qualify if…
- Proficiency in languages other than English or Chinese
- History of or current complaint of hearing loss or tinnitus
- History of or current complaint of cognitive impairments
- Individuals with more than 5 years of formal music experience or training
- Complaints of impaired speech perception in noise
Where it is running
- Northwestern University — Evanston, Illinois, United States
Full record on ClinicalTrials.gov
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