Insulin Sensitivity After Breast Cancer

Recruiting now · Not applicable

Conditions studied: Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance

In brief

Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the major site of glucose uptake in humans. The aims of the present project are to 1) determine the involvement of insulin resistance in skeletal muscle in the metabolic disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular changes in skeletal muscle from BC survivors .

Key facts

Study ID

NCT05010356

Run by

University of Copenhagen

People needed

24

Starts

2021-08-01

Expected to finish

2026-09-01

Last updated by the study team

2021-08-18

Who can join

Age: 20 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Premenopausal women operated for breast cancer and after completing adjuvant chemotherapy and no earlier than 3 weeks after its termination
• BMI: 25-30
• Healthy controls will be included matched by gender, weight, age, and level of physical activity to the patient group included as subjects

You may not qualify if…

• Known postmenopause occurred at the time of diagnosis of breast cancer
• Alcohol intake of> 7 items / week
• Smoker
• Already known Type 2 diabetes mellitus or metabolic syndrome and medical treatment thereof.
• Cardiovascular disease and its medical treatment
• Impaired mobility

Where it is running

• University of Copenhagen — Copenhagen, DK, Denmark (enrolling)

Full record on ClinicalTrials.gov

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