A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

Recruiting now · Phase 2

Conditions studied: Metastatic Cancer

In brief

This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would still be effective to treat these tumors.

Key facts

Study ID

NCT05010031

Run by

Memorial Sloan Kettering Cancer Center

People needed

45

Starts

2021-08-11

Expected to finish

2027-08-01

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed malignancy with at least one metastatic lesion referred for palliative radiotherapy
• Pathogenic mutation in ATM (somatic and germline allowed)
• ECOG performance status 0-2
• Age ≥ 18 years.
• Able to provide informed consent.
• Patients at reproductive potential must agree to practice an effective contraceptive method during radiation treatments.
• Expected life expectancy of at least 6 months

You may not qualify if…

• Previous radiotherapy to the intended treatment site that precludes developing a treatment plan that respects normal tissue tolerances.
• Serious medical co-morbidities precluding radiotherapy.
• Pregnant or breast-feeding women.
• Lesions excluded from de-escalation include regions in which the risk of local disease progression is unacceptably high, including CNS disease and cord compression, and areas in which re-irradiation would not be feasible, including spinal cord overlap.

Where it is running

• Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (All protocol activities) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Bergen (All protocol activities) — Montvale, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Commack (All protocol activities) — Commack, New York, United States (enrolling)
• Memorial Sloan Kettering Westchester (All Protocol Activities) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Nassau (All protocol activities) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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