MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

Status unconfirmed · Not applicable

Conditions studied: Traumatic Brain Injury, Major Depressive Disorder

In brief

The goal of this proposal is to examine the influence of feedback timing on learning and brain function in individuals with moderate-to-severe traumatic brain injury (TBI), with and without depression.

Key facts

Study ID

NCT05009511

Run by

Kessler Foundation

People needed

180

Starts

2021-09-01

Expected to finish

2026-01-31

Last updated by the study team

2024-10-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• I am between the ages of 18 and 65.
• I have been diagnosed with a TBI.
• I am an individual without TBI.
• I am right-handed.
• I have normal vision or corrected to normal vision.
• I can read and speak English fluently.
• I do or do not have a current diagnosis of Depression.
• I am not currently pregnant.

You may not qualify if…

• I have had a neurological disease, other than TBI.
• I have a significant history of alcohol or drug abuse as determined by study staff.
• I have metal in my body (shrapnel, piercing that cannot be taken off, retainer on the upper jaw).
• I have something in my body that restricts me from having an MRI such as: an aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant (internal hearing aids); ocular foreign body (e.g. metal shavings in my eye), insulin pump or any pre- existing eye conditions (such as blurry vision, seeing double, and abnormal eye movements).
• I experience discomfort in closed spaces (claustrophobia).
• I have been diagnosed with a neurologic illness such as epilepsy, brain tumors, etc. (e.g. schizophrenia and bipolar disorder).
• I have had corticosteroid treatment less than a month ago as determined by study staff review of my medications.
• I have been informed by my doctor that is it unsafe for me to receive regular MRI as part of my medical care.

Where it is running

• Kessler Foundation — West Orange, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.