Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia

Stopped early

Conditions studied: AMN, AMN Gene Mutation, X-ALD

In brief

The course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments. This study will help obtain a better understanding of the progression of disease with AMN and facilitate efficient clinical development of future interventional medications.

Key facts

Study ID

NCT05008874

Run by

SwanBio Therapeutics, Inc.

People needed

65

Starts

2021-06-21

Expected to finish

2025-05-16

Last updated by the study team

2025-10-30

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male adults aged ≥18 years
• Diagnosed with ALD based on elevated VLCFA assay and pedigree analysis
• Clinical evidence of spinal cord involvement with EDSS score between 1 and 6.5

You may not qualify if…

• Diagnosed with cerebral inflammatory disease or has a history of diagnosis with cerebral inflammatory disease
• Unstable, clinically significant neurologic (other than the disease being studied), psychiatric, cardiovascular, ophthalmologic, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, hematopoietic, or endocrine disease (other than adrenal insufficiency) or other abnormality, which may impact the ability to participate in the study or that may potentially confound the study results
• Participant who, in the opinion of the Investigator, has any other medical or psychological condition or social circumstances which would impair their ability to participate reliably in the assessments, or who may increase the risk to themselves or others by participating

Where it is running

• Stanford Neuroscience Health Center — Stanford, California, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Weill Medical College of Cornell University — New York, New York, United States
• University of Utah — Salt Lake City, Utah, United States
• University of Leipzig Medical Center — Leipzig, Germany
• Amsterdam UMC — Amsterdam, Netherlands

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.