Imaging CRF X NOP Interactions in CUD
Recruiting now · Early Phase 1
Conditions studied: Cocaine Use Disorder
In brief
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
Key facts
- Study ID
- NCT05008146
- Run by
- Rajesh Narendran
- People needed
- 80
- Starts
- 2020-12-31
- Expected to finish
- 2028-09-01
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
Where it is running
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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