Study to Determine the Antitumor Activity of New CAR-macrophages in Breast Cancer Patients' Derived Organoids

Recruiting now

Conditions studied: Breast Cancer

In brief

Cell-based immune therapy using modified macrophages is a promising therapeutic approach in breast cancer. The objective of this cohort study is to collect tumor samples to develop patients' derived organoids to test the antitumor activity of newly developed CAR-macrophages. Other biological samples will be collected such as blood to analyze the host inflammatory status.

Key facts

Study ID

NCT05007379

Run by

Centre Oscar Lambret

People needed

100

Starts

2021-11-02

Expected to finish

2027-12-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female aged 18 years or more
• Histologically confirmed breast cancer at any stage
• Requiring surgery or tumor biopsy as standard of care
• Any or no systemic treatment
• Signed informaed consent
• Health insurance coverage

You may not qualify if…

• Opposed to biospecimen collection

Where it is running

• Oscar Lambret Center — Lille, France (enrolling)

Full record on ClinicalTrials.gov

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