Comparison Neuromuscular Blockade Monitors

Completed

Conditions studied: Neuromuscular Blockade

In brief

The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known as "twitch monitoring"). The specific aim is to compare mechanomyography, which is the "gold standard" laboratory measurement to assess neuromuscular blockade, to the sensors used in commercially available neuromuscular blockade monitors, such as acceleromyography and electromyography. The study endpoints are the train-of-four count (TOFC), the ratio of the height of the 4th twitch to the height of the 1st twitch (train-of-four ratio, TOFR), and the post tetanic count (PTC). The mechanomyography devices have been constructed in our laboratory and are not commercially available.

Key facts

Study ID

NCT05006807

Run by

University of Washington

People needed

51

Starts

2022-02-01

Expected to finish

2024-12-01

Last updated by the study team

2026-07-08

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or greater
• Undergoing anesthesia that requires neuromuscular blocking drugs

You may not qualify if…

• Less than 18 years of age
• Undergoing anesthesia that does not require neuromuscular blocking drugs
• Undergoing a procedure in which access to one or both arms is limited
• Anatomical abnormalities of the hands or arms that preclude twitch monitoring with ulnar nerve stimulation and evoked thumb twitch response

Where it is running

• University of Washington Medical Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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