Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

Completed · Not applicable

Conditions studied: Post-operative Pain, Acute

In brief

The purpose of this study is to determine whether the addition of magnesium to bupivacaine for the post-operative adductor canal blocks (ACB) can decrease opioid consumption and improve pain management for patients after same-day discharge total knee arthroplasty (TKA). The investigators will assess whether the addition of magnesium will decrease visual analog scale (VAS) pain scores, decrease post-operative total opioid consumption (oral morphine equivalents), decrease the incidence of post-operative nausea and vomiting (PONV), and improve patient satisfaction in comparison to when magnesium is not administered.

Key facts

Study ID: NCT05004636
Run by: Wayne State University
People needed: 119
Starts: 2020-08-05
Expected to finish: 2021-05-29
Last updated by the study team: 2021-08-13

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients undergoing unilateral primary total knee arthroplasty with spinal anesthetic and MAC followed by a unilateral adductor canal block with ultrasound guidance.

You may not qualify if…

Patients on chronic anticoagulation upon admission
Patients with significant genetic or acquired clotting/bleeding disorders (hemophilia, DIC, etc.) or significant platelet dysfunction
Patients with prior back surgery or leg surgery that precludes spinal or regional anesthesia
Infection at sites for regional/spinal anesthesia
Allergy to local anesthetics

Where it is running

St. Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States

Full record on ClinicalTrials.gov

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