Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies

Completed

Conditions studied: Vanishing Twin, Trisomy 21, Trisomy 13, Trisomy 18

In brief

The purpose of this study is to collect blood samples from women carrying a vanishing twin pregnancy to further develop Natera's non-invasive prenatal screening test to provide information about possible chromosomal conditions for the living twin

Key facts

Study ID

NCT05004337

Run by

Natera, Inc.

People needed

126

Starts

2021-07-22

Expected to finish

2023-11-29

Last updated by the study team

2024-09-25

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women with either ultrasound-documented dizygotic (DZ) twin pregnancy or those whose Panorama Test™ results suggest increased risk for vanishing twin

You may not qualify if…

• Monozygotic twin pregnancy
• Non twin pregnancy
• Maternal history of bone marrow or organ transplantation

Where it is running

• Center for Fetal Medicine & Women's Ultrasound — Los Angeles, California, United States
• Stanford — Palo Alto, California, United States
• University of Colorado — Aurora, Colorado, United States
• Yale — New Haven, Connecticut, United States
• Christiana Care — Newark, Delaware, United States
• Emerald Coast ObGyn — Panama City, Florida, United States
• University of Kansas — Kansas City, Kansas, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Beaumont — Royal Oak, Michigan, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Hackensack — Neptune City, New Jersey, United States
• St. Peter's University Hospital — New Brunswick, New Jersey, United States
• NYU Long Island — Mineola, New York, United States
• NYU Langone — New York, New York, United States
• Icahn School of Medicine at Mount Sinai Hospital — New York, New York, United States
• Columbia University — New York, New York, United States
• Weill Cornell Medicine — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• Lehigh Valley Health Network — Allentown, Pennsylvania, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Cedar Health Research — Irving, Texas, United States

Full record on ClinicalTrials.gov

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