Effects of Acetylcholine and Attention on Visual Spatial Representations in the Brain

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Visual Perception, Attention, Information Processing, Cholinergic System

In brief

This study in, healthy human subjects using fMRI and MRS (magnetic resonance spectroscopy) characterizes, how attention and acetylcholine affect visual perception and the brain's representation of the visual environment. Levels of acetylcholine in the cerebral cortex will be enhanced by administration of donepezil, an inhibitor of acetylcholinesterase. Half the subjects will receive donepezil and other half will receive placebo.

Key facts

Study ID

NCT05003063

Run by

University of California, Berkeley

People needed

12

Starts

2021-02-04

Expected to finish

2021-08-02

Last updated by the study team

2021-08-12

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult individuals

You may not qualify if…

• Pregnancy
• Asthma/lung problems
• Certain medications, seizure
• Failure to complete Donepezil (Aricept) Contraindications Screening Sheet
• Previous long term exposure to nicotine/tobacco products, individuals with pacemakers, cosmetics, or certain metallic implants in their bodies will be excluded from experiments involving MRI recording.

Where it is running

• University of California, Berkeley — Berkeley, California, United States

Full record on ClinicalTrials.gov

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