A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
Running, not enrolling · Phase 2/Phase 3
Conditions studied: Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Gastric Adenocarcinoma
In brief
A Phase 2/3 Study of Evorpacept (ALX148) in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Patients With Advanced HER2-overexpressing gastric/GEJ adenocarcinoma.
Key facts
- Study ID
- NCT05002127
- Run by
- ALX Oncology Inc.
- People needed
- 127
- Starts
- 2022-01-15
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2025-08-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- HER2-overexpressing advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma that has progressed on or after a prior HER2-directed agent and fluoropyrimidine- or platinum-containing chemotherapy (2nd-line or 3rd-line)
- Adequate Bone Marrow Function.
- Adequate Renal \& Liver Function.
- Adequate Performance Status
You may not qualify if…
- Patients with known symptomatic central nervous system (CNS) metastases or leptomeningeal disease requiring steroids.
- Prior treatment with any anti-CD47 or anti-SIRPα agent.
- Prior treatment with ramucirumab.
Where it is running
- University of California Los Angeles — Los Angeles, California, United States
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
- NEXT Virginia — Fairfax, Virginia, United States
- Fred Hutchinson Cancer Center — Seattle, Washington, United States
- Icon Cancer Centre Southport — Southport, Queensland, Australia
- Monash Medical Centre — Clayton, Victoria, Australia
- Universitair Ziekenhuis Antwerpen — Antwerp, Belgium
- Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven, Belgium
- Centre Hospitalier Universitaire de Liège — Liège, Belgium
- Fakultní Nemocnice Hradec Králové — Hradec Králové, Czechia
- Fakultní Nemocnice Olomouc — Olomouc, Czechia
- Vseobecna Fakultni Nemocnice v Praze — Prague, Czechia
- Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz — Besançon, France
- Centre Hospitalier Universitaire de Bordeaux — Bordeaux, France
- Hôpital Morvan — Brest, France
- Centre Léon Bérard — Lyon, France
- Hôpital Privé Jean Mermoz — Lyon, France
- Institut Paoli-Calmettes — Marseille, France
- Hôpital Saint-Antoine — Paris, France
- Hôpital Trousseau — Paris, France
- Hôpital Rangueil — Toulouse, France
- Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi — Catania, Italy
- Azienda Ospedaliero - Universitaria Careggi — Florence, Italy
- Fondazione IRCCS - Istituto Nazionale dei Tumori — Milan, Italy
- The Oncology Institute of Hope & Innovation — Anaheim, California, United States
Full record on ClinicalTrials.gov
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