Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?
Recruiting now · Phase 1
Conditions studied: Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
In brief
The principal objective of this study is to compare the incidence of ventriculostomy related infections (VRIs) in patients who receive twenty-four hours of antibiotics, beginning no more than sixty minutes prior to EVD placement, to the incidence of VRIs in patients who also receive a pre-procedural dose of antibiotics with continued dosing of antibiotics for the duration of the external ventricular drain (EVD). At this time, the duration of prophylactic antibiotic use with antibiotic impregnated EVDs is unknown.
Key facts
- Study ID
- NCT05001750
- Run by
- Montefiore Medical Center
- People needed
- 84
- Starts
- 2021-06-14
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients over the age of 18 years
- patients diagnosed with a subarachnoid hemorrhage, intracerebral hemorrhage, or acute ischemic stroke who require an EVD for management of their underlying condition. In certain cases (a small minority), an EVD must be replaced due to failure (i.e., blood clot interrupting flow). In such cases, patients will be re-dosed with antibiotics prior to catheter exchange in typical fashion and continue in their previously randomized treatment group
You may not qualify if…
- patients who were on antibiotics within the week prior to admission
- patients with leukopenia (<5000) at baseline
- patients with signs of meningitis, ventriculitis or any other infection at presentation
- patients who are pregnant or prisoners
- patients aged < 18 years old
Where it is running
- Montefiore Medical Center — The Bronx, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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