Long Term Follow-up of Patients With Prosthetic Joint Infection of the Hip Treated at University Hospitals Leuven

Recruiting now

Conditions studied: Prosthetic Joint Infection, Hip Prosthesis Infection

In brief

Prosthetic Joint Infection (PJI) of a Total Hip Replacement (THR) is a disastrous complication of an otherwise extremely successful surgical procedure. It is associated with a burdensome treatment for the patient, significant challenges for the medical team and high costs for society. As more joint replacements are being performed each year, due to an ageing population and lower thresholds for surgery, the number of PJIs is on the rise. Many of these patients will be referred to University Hospitals Leuven as the physicians have extensive experience with this particular pathology and can offer a multidisciplinary and patient-tailored treatment. Many controversies exist in the field of PJI treatment, both with regard to the surgical aspects as well as the antibiotic treatment. Setting up randomized controlled trials to answer these questions has been proven to be very difficult due to large variations in patients, implants, germs, soft and hard tissues, antibiotic resistance patterns, and so on. Also, surgery for PJIs is usually non-elective / semi-urgent and therefore time to include patients into different trials is limited. Therefore the investigators will prospectively collect data on patients with PJI treated at University Hospitals Leuven, starting 01/01/2022, in order to have knowledge of own results and inform patients about chances of success prior to treatment; perform internal audits and quality checks; answer questions in the field of PJI treatment not suitable for RCTs.

Key facts

Study ID

NCT05000723

Run by

Universitaire Ziekenhuizen KU Leuven

People needed

50

Starts

2022-07-14

Expected to finish

2099-12-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older
• patients diagnosed with PJI of the hip based on EBJIS 2021 criteria

You may not qualify if…

• Patients unable to provide written informed consent
• Patients who prefer treatment outside of University Hospitals Leuven
• Patients with infections of the native hip joint
• Patients with fracture-related infections (FRI)
• Patients with uncertain diagnosis of PJI according to the 2021 EBJIS criteria
• Patient younger than 18 years

Where it is running

• University Hospitals Leuven - Gasthuisberg — Leuven, Belgium (enrolling)

Full record on ClinicalTrials.gov

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