Prospective Evaluation of Targeted Axillary Dissection (TAD)
Completed · Not applicable
Conditions studied: Breast Cancer
In brief
The purpose of this research is to evaluate how to manage the axillary lymph nodes in patients with breast cancer. The investigators will determine if a sampling of the lymph nodes under the arm will give the information necessary to determine if fewer lymph nodes can be removed.
Key facts
- Study ID
- NCT04998682
- Run by
- University of Miami
- People needed
- 20
- Starts
- 2022-03-01
- Expected to finish
- 2026-02-11
- Last updated by the study team
- 2026-03-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Women or men greater than or equal to 18 years.
- Histologically confirmed invasive adenocarcinoma of the breast.
- Clinical T0-4 N2-3 M0 at diagnosis (American Joint Committee on Cancer, 7th Edition)
- Assessment for cN2 disease will be performed by clinical exam and imaging. Patients should have pathologic level 1 and/or 2 axillary lymph nodes which are fixed/matted on physical exam.
- Cross-sectional imaging will be used to identify advanced nodal disease involving the axilla, infraclavicular, supraclavicular, and internal mammary regions, cN3 disease.
- Patients must have biopsy proven involvement of the axillary lymph nodes.
- Receipt of standard multiagent chemotherapy +/- targeted therapy based on tumor subtype.
- Candidate for surgical management of breast cancer.
- Ability to understand and willingness to sign a written informed consent document.
You may not qualify if…
- History of allergic reactions or hypersensitivity to radioactive lymph node mapping agents or blue dye.
- Pregnancy.
Where it is running
- University of Miami — Miami, Florida, United States
Full record on ClinicalTrials.gov
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