Study of Plozasiran (ARO-APOC3) in Adults With Mixed Dyslipidemia
Completed · Phase 2 · Has a placebo group
Conditions studied: Mixed Dyslipidemia
In brief
Participants who have met all protocol eligibility criteria will be randomly assigned to treatment (ARO-APOC3 or placebo) in a double-blind fashion and will be evaluated for safety and efficacy over 48 weeks. Participants will be counseled to remain on a specified diet throughout the study, as recommended by the Investigator in accordance with local standards of care. After week 48, participants will be eligible and invited to consent and continue in an open-label extension study. All placebo participants who opt to continue will switch to active drug (ARO-APOC3) during the extension study.
Key facts
- Study ID
- NCT04998201
- Run by
- Arrowhead Pharmaceuticals
- People needed
- 353
- Starts
- 2021-09-28
- Expected to finish
- 2023-08-14
- Last updated by the study team
- 2026-04-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site 3 — Beverly Hills, California, United States
- Research Site 8 — Northridge, California, United States
- Research Site 2 — Boca Raton, Florida, United States
- Research Site 1 — Fort Lauderdale, Florida, United States
- Research Site 14 — Miami Springs, Florida, United States
- Research Site 5 — Pembroke Pines, Florida, United States
- Research Site 18 — Dunwoody, Georgia, United States
- Research Site 31 — Las Vegas, Nevada, United States
- Research Site 17 — New Windsor, New York, United States
- Research Site 12 — Dayton, Ohio, United States
- Research Site 4 — Franklin, Ohio, United States
- Research Site 7 — Greenville, South Carolina, United States
- Research Site 6 — Houston, Texas, United States
- Research Site 32 — Houston, Texas, United States
- Research Site 13 — San Antonio, Texas, United States
- Research Site 30 — Morayfield, Queensland, Australia
- Research Site 29 — Adelaide, South Australia, Australia
- Research Site 19 — Clayton, Victoria, Australia
- Research Site 27 — Joondalup, Western Australia, Australia
- Research Site 15 — Concord, Ontario, Canada
- Research Site 10 — Montreal, Quebec, Canada
- Research Site 20 — Balatonfüred, Hungary
- Research Site 21 — Debrecen, Hungary
- Research Site 22 — Nyíregyháza, Hungary
- Research Site 11 — Auckland, New Zealand
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.