(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
Recruiting now · Phase 2
Conditions studied: Advanced Systemic Mastocytosis (AdvSM), SM With an Associated Hematologic Neoplasm (SM-AHN), Mast Cell Leukemia (MCL), Aggressive Systemic Mastocytosis (ASM)
In brief
This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL).
Key facts
- Study ID
- NCT04996875
- Run by
- Cogent Biosciences, Inc.
- People needed
- 140
- Starts
- 2021-11-09
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Stanford Cancer Institute — Stanford, California, United States (enrolling)
- MUSC Health University Medical Center — Charleston, South Carolina, United States (enrolling)
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Huntsman Cancer Institute - University of Utah Health — Salt Lake City, Utah, United States (enrolling)
- Nepean Hospital — Kingswood, New South Wales, Australia (enrolling)
- Gold Coast University Hospital — Southport, Queensland, Australia (enrolling)
- Peter MacCallum Cancer Centre — Melbourne N., Victoria, Australia (enrolling)
- Mayo Clinic Arizona — Phoenix, Arizona, United States (enrolling)
- Winship Cancer Institute - Emory University — Atlanta, Georgia, United States (enrolling)
- University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)
- St. Michael's Hospital - Unity Health Toronto — Toronto, Ontario, Canada (enrolling)
- City of Hope Comprehensive Cancer Center — Duarte, California, United States (enrolling)
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
- UCLA Medical Center — Los Angeles, California, United States (enrolling)
- Universitätsspital Basel — Basel, Switzerland (enrolling)
- Guy's Hospital - NHS Foundation Trust — London, London, United Kingdom (enrolling)
- Leeds Teaching Hospitals NHS Trust — Leeds, United Kingdom (enrolling)
- University College London Hospital - NHS Foundation Trust — London, United Kingdom (enrolling)
- University Medical Center Groningen — Groningen, Netherlands
- Oslo University Hospital — Oslo, Norway
- Public University Hospital No. 1 in Lublin — Lublin, Poland
- Hospital Universitario Vall d'Hebron — Barcelona, Spain
- University of Alabama at Birmingham (UAB) Hospital — Birmingham, Alabama, United States
- Hospital Universitario Ramón y Cajal — Madrid, Spain
- Institut Català d'Oncologia - Hospital Duran i Reynals — Barcelona, Spain
Full record on ClinicalTrials.gov
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